Cosmetic-grade Sodium DNA (PDRN),
made by the people who sign the COA.Cosmetic-grade Sodium DNA
(PDRN), made by Helio.
From wild North Pacific salmon milt through extraction, molecular-weight fractionation, purification and release testing — all run in-house under ISO 22716 cosmetics GMP.Wild-salmon origin, controlled molecular weight and batch-level proof — under ISO 22716 cosmetics GMP.
Per-batch COA · independent third-party retest · IECIC No.383
A US company that makes its own material — in the US and in China.
We own the factories and the supply chain in the US and China, and run the full sequence in-house — extraction, molecular-weight fractionation, purification, release testing — under ISO 22716 cosmetics GMP. A maker, not a middleman: the people who set the molecular weight are the people who sign the COA.
Manufacturing & delivery
Manufactured under an ISO 22716 cosmetics GMP system, supporting formulation trials through commercial supply; delivery plans are confirmed by project.
ISO 22716 GMP
Cleanroom manufacturing with in-process control at every step — not inspection bolted on at the end.
Science & R&D
A material behind 600+ published papers, and confirmed on our side by a per-batch COA with independent third-party retest.
Specifications a formulator can audit
Sodium DNA (PDRN) from salmon milt, fractionated to the molecular weight cosmetics actually want — every value stated with the method behind it, and verified batch by batch. Nothing here you have to take on faith.
| INCI Name | Sodium DNA (PDRN) |
| CAS No. | 68938-01-2 |
| Cosmetic function | Skin conditioning agent |
| Source | North Pacific wild-salmon milt |
| Assay | ≥99% (99.35%, HPLC-UV) |
| Molecular weight | ≤1000 kDa (SEC) · sweet spot 80–200 kDa |
| Purity ratio UV260/280 | 1.8–2.0 (measured 1.9) |
| Appearance | Solution (primary) / off-white powder |
| Microbial · heavy metals | Conforms (see COA) |
| Shelf life | 36 months |
Available on request · TDS · SPEC · SDS/MSDS · COA · stability · literature pack
Compliance & documentation
- Filed on China IECIC (No.383, Sodium DNA) — compliant for use in China
- Manufactured under ISO 22716 (cosmetics GMP)
- Per-batch Certificate of Analysis + independent third-party retest
- Wild-caught source: BSE/TSE-free, free from antibiotics and aquaculture contaminants; traceable
Real PDRN, or PDRN in name only?
Open each proof point to compare the Helio process with common alternatives.
| Quality dimension | Conventional preparation | The Helio process |
|---|---|---|
| Source | Mixed tissues, variable DNA integrity | Salmon milt only — DNA-rich, highest integrity |
| MW control | Broad fragment distribution, batch drift | Controlled to the cosmetic sweet spot; narrow & consistent |
| Purity & residue | Higher residual protein / impurities | ≥99% assay, low residual protein, UV260/280 ≈ 1.9 |
| Activity | Harsh processing degrades DNA structure | Mild enzymatic process preserves native double-strand integrity |
| Batch consistency | Wide batch-to-batch variance | GMP + in-line QC — highly consistent, scalable |
Source
MW control
Purity & residue
Activity
Batch consistency
One active, many pathways — and no weak axis
In the published PDRN literature it acts as an A2A adenosine-receptor agonist, associated with fibroblast and extracellular-matrix activity. What that means for a formulator: a single active that reads well across barrier support, soothing, antioxidant, brightening and hydration — broad, well-tolerated, and with no weak axis to design around.
Figures reflect category / literature-level data on polynucleotides / Sodium DNA (in-vitro, ex-vivo and human studies; illustrative) — not single-batch Helio or finished-product results. Finished-product performance and claims are the responsibility of the brand under the regulations of its market. Sodium DNA's cosmetic function is skin conditioning; this page carries no medical, therapeutic, wound-healing, tissue-regeneration or injectable claims. Injectable / medical grade is a separate product line.
Real PDRN versus PDRN in name only — the buyer's biggest trap
PDRN is one of the fastest-growing actives in skincare — which is exactly why so much of what's sold as "PDRN" isn't. Hydrolyzed DNA, plant-based, recombinant stand-ins — moving without an INCI, a CAS, a molecular weight or a COA to stand behind them. Helio is the real thing: a named wild-salmon origin, molecular weight held under control, provable in every batch. In a category this easy to fake, that verifiability is the moat between your brand and a recall.
| Process route | INCI authenticity | MW control | Provable purity | Traceability · manufacturing |
|---|---|---|---|---|
| Helio: wild-salmon milt · enzymatic purification | Genuine Sodium DNA | Controlled to the 80–200 kDa active window | 99.35% + per-batch COA + third-party retest | Per-batch traceable · own factories |
| Recombinant / synthetic-biology 'PDRN' | Name-similar, not fish-derived native DNA | Sequence-customizable | Maker-dependent | Not resource-dependent |
| Hydrolyzed DNA | Degraded fragments, not intact PDRN | Broad, hard to control | Often no MW / COA | Inconsistent |
| Plant-based 'PDRN' | No genuine nucleotide active | — | — | Largely a marketing concept |
A neutral comparison, not a swipe at anyone: "natural extraction" here means the genuine salmon-milt material with batch-to-batch consistency, not the instability that dogs improvised sources. Specify the real thing and you stop carrying someone else's compliance and QC risk.
Source: category-level industry research (QYR / Deloitte / Everbright Securities), 2025 — PDRN category basis.
Download the technical brochure
A complete B2B technical brochure — specifications, process, efficacy literature, compliance and a market overview. Direct PDF download, no sign-up. For the COA and full dossier, use the request form below.
Download brochure (PDF)Also available on request: TDS / SPEC / SDS / COA / stability / literature pack (see the form below).